ea0022p50 | Adrenal | ECE2010
Lenzini Livia
, Seccia Teresa Maria
, Caroccia Brasilina
, Recarti Chiara
, Pelizzo Maria Rosa
, Rossi GianPaolo
Background: Primary aldosteronism is a common cause of arterial hypertension, but its underlying molecular mechanisms are unknown. K+ is a key regulator of aldosterone secretion: it interacts with physiological secretagogues of aldosterone as angiotensin II (Ang II) end endothelin-1. In vivo genetic manipulation of a widely distributed class of channels, which generate background or leak potassium (K+) currents, the twik-related acid-se...